Rhizome of Chinese Goldthread — Safety & Interactions
Chuan Huang Lian · Rhizoma Coptidis
Use with caution. Practitioner review recommended before use.
Contraindications
- Spleen and Stomach deficiency cold — primary TCM contraindication
- Yin deficiency with secondary Heat signs
- Blood deficiency patterns with secondary Heat
- Jaundiced neonates — berberine displaces bilirubin; do not administer to newborns with jaundice
Cautions
- May prolong QTc interval in patients with underlying heart disease; use with caution in cardiac conditions
- Use with caution during pregnancy — intensely cold properties may disturb gestational balance
- Breastfeeding: use with caution; berberine transfers into breast milk
Drug Interactions
| Drug Class / Substrate | Mechanism | Severity | Source |
|---|---|---|---|
| CYP2D6, CYP2C9, and CYP3A4 substrate drugs | Huanglian inhibits CYP2D6, CYP2C9, and CYP3A4; may increase plasma levels and side effects of substrate drugs. Prolonged use may also induce CYP3A4, potentially decreasing drug concentrations | Unknown | Memorial Sloan Kettering |
This information is for educational purposes only and does not constitute medical advice. Always consult a qualified healthcare provider before using herbal medicines, especially if you take prescription medications.