Red Yeast Rice … Safety & Interactions

Hong Qu · Semen Oryzae Cum Monasco Fermentatum

Contraindications

  • Pregnancy or breastfeeding
  • Active liver disease, prior statin intolerance, or unexplained muscle symptoms
  • Concurrent prescription statin use without professional supervision

Cautions

  • Modern red yeast rice products can behave like low-dose statin exposure, and potency varies widely across brands and batches.
  • Some commercial preparations may also contain citrinin or other fermentation byproducts, so supplement quality matters more here than with ordinary culinary red rice.
  • Traditional Hong Qu as a medicinal fermented grain should not be assumed equivalent to standardized or non-standardized capsule products.

Drug Interactions

Drug Class / Substrate Mechanism Severity Source
Statins ... possible additive myopathy or liver-enzyme risk
Cyclosporine or strong CYP3A4 inhibitors ... possible increase in monacolin exposure
Fibrates or high-dose niacin ... possible increase in muscle-related adverse effects

Pregnancy

Not recommended during pregnancy. Consult a qualified practitioner before any use.

This information is for educational purposes only and does not constitute medical advice. Always consult a qualified healthcare provider before using herbal medicines, especially if you take prescription medications.