Purpleflower Crotalaria Herb … Safety & Interactions
Nong Ji Li · Herba Crotalariae
Contraindicated / High risk. Use only under practitioner supervision.
Contraindications
- Pregnancy
- Pre-existing liver disease or elevated liver enzymes
- Paediatric use
- Concurrent hepatotoxic drug therapy
Cautions
- Crotalaria sessiliflora contains pyrrolizidine alkaloids, especially monocrotaline-related chemistry, and should be treated as a hepatotoxic high-risk herb rather than a casual folk tonic.
- Short-term symptom relief or historical antitumor use does not remove the risk of cumulative liver injury, vascular toxicity, or broader heavy-exposure harm.
- Source confusion with other Crotalaria species can worsen both efficacy uncertainty and toxicology risk.
Drug Interactions
| Drug Class / Substrate | Mechanism | Severity | Source |
|---|---|---|---|
| Hepatotoxic drugs ... additive liver-injury risk | |||
| CYP3A4 or CYP2A6 modifying drugs ... may alter metabolic activation of toxic pyrrolizidine alkaloids | |||
Pregnancy
Not recommended during pregnancy. Consult a qualified practitioner before any use.
This information is for educational purposes only and does not constitute medical advice. Always consult a qualified healthcare provider before using herbal medicines, especially if you take prescription medications.