Epimedium Herb (Xian Ling Pi — Synonym) — Safety & Interactions
Xian Ling Pi · Herba Epimedii
Use with caution. Practitioner review recommended before use.
Contraindications
- Yin deficiency with Heat signs
- Hormone-sensitive conditions (breast cancer, endometriosis) — estrogenic activity
Cautions
- Standard dose 6–15g decoction
- This entry (herb #61, Xian Ling Pi) is a synonym of herb #60 (Yin Yang Huo) — identical species, identical safety and drug interaction profile
- See herb #60 for full drug interaction detail: aromatase inhibitors, PDE5 inhibitors, CYP3A4 substrates
Drug Interactions
| Drug Class / Substrate | Mechanism | Severity | Source |
|---|---|---|---|
| Aromatase inhibitors (anastrozole, exemestane, letrozole): icariin promotes aromatase activity — potential reduction in drug efficacy | |||
| PDE5 inhibitors (sildenafil, tadalafil): pharmacodynamic additive effect; avoid concurrent use | |||
| CYP3A4 substrates: prolonged use may induce CYP3A4 | |||
This information is for educational purposes only and does not constitute medical advice. Always consult a qualified healthcare provider before using herbal medicines, especially if you take prescription medications.