Medication evidence for saw palmetto is inconsistent. NCCIH reports that interactions have not been demonstrated, while MSK notes bleeding case reports and laboratory effects on CYP and UGT enzymes.

Use with caution. Healthcare professional review recommended before use.

Contraindications

Pregnancy or breastfeeding
Use before surgery without medical guidance

Cautions

Most safety data come from studies in men.
Digestive symptoms, dizziness, and headache can occur.
NCCIH reports no demonstrated medication interaction, while MSK notes bleeding case reports and preclinical enzyme effects.

Drug Interactions

Drug Class / Substrate	Mechanism	Severity	Source
Anticoagulants and antiplatelet medicines	Case reports suggest additive bleeding effects, but a consistent clinical interaction has not been established.	Moderate	Memorial Sloan Kettering About Herbs
Nonsteroidal anti-inflammatory drugs	A case report raised concern for increased adverse effects and bleeding.	Uncertain	Memorial Sloan Kettering About Herbs
CYP3A4, CYP2D6, CYP2C9, and UGT substrate medicines	Laboratory inhibition has been reported, but clinical relevance is not known.	Uncertain	Memorial Sloan Kettering About Herbs

Pregnancy

Not recommended during pregnancy. Consult a qualified healthcare provider before any use.

This information is for educational purposes only and does not constitute medical advice. Always consult a qualified healthcare provider before using herbal medicines, especially if you take prescription medications.