Rhizome of Radde Anemone
- Pinyin
- Zhu Jie Xiang Fu
- Latin
- Rhizoma Anemones Raddeanae
This pungent, hot herb enters the Spleen. Traditionally, it dispels wind-damp and relieves stubborn joint pain ... Zhu Jie Xiang Fu is used for cold-damp obstruction, aching limbs, and painful joints with a resistant quality, most often applied for rheumatism, joint pain, and abscess. Modern research has identified Raddeanin among its active constituents.
Part used: Rhizome
Also Known As
Latin: Rhizoma Anemones Raddeanae | Pinyin: Zhu Jie Xiang Fu
TCM Properties
- Taste
- pungent
- Temperature
- hot
- Channels
- Spleen
Traditional Use
Primary Actions
- Dispels wind-damp and relieves stubborn joint pain ... Zhu Jie Xiang Fu is used for cold-damp obstruction, aching limbs, and painful joints with a resistant quality.
- Reduces swelling and relieves fixed obstructive pain ... traditional use includes painful swellings, neuralgia-type discomfort, and hard obstructive soreness.
- Resolves toxic swellings in the broader Anemone raddeana tradition ... older use extends to boils, carbuncles, and inflamed lesions where a hot toxic rhizome was chosen.
Secondary Actions
- This page follows the trade-rhizome-forward Zhu Jie Xiang Fu naming lane of Anemone raddeana rather than the more classical Liang Tou Jian naming kept in `radde-anemone-rhizome`.
- The hot toxic profile matters ... modern antitumor interest does not make this a casual pain or cancer herb.
Classic Formulas
- Wind-damp pain combinations pair Zhu Jie Xiang Fu with Qin Jiao or Wei Ling Xian when cold obstruction and joint pain dominate.
- Swelling and fixed-pain patterns combine it with Ru Xiang or Mo Yao when the goal is to break resistant painful accumulations.
- Toxic-swelling folk combinations pair it with Jin Yin Hua or Pu Gong Ying when hot swollen lesions are prominent.
Classical References
- Traditional sources on Anemone raddeana describe the rhizome as pungent, hot, and toxic, used mainly for wind-damp pain and swelling.
- The clinical distinction from Liang Tou Jian here is mostly naming emphasis and trade presentation, not a different species or radically different pharmacology.
Modern Research
Active Compounds
- Raddeanin A and related triterpenoid saponins ... the best-known modern constituents
- Oleanane-type pentacyclic triterpenoids ... a major structural family in Anemone raddeana rhizome
- Lupeol, betulin, and betulinic-acid derivatives ... supportive anti-inflammatory and cytotoxic fractions
Studied Effects
- A 2018 review summarized the chemistry and pharmacological effects of Anemone raddeana rhizome and confirmed its longstanding use for neuralgia and rheumatism (PMID 28986812).
- A 2018 analytical study profiled cytotoxic triterpenoids in the rhizomes of Anemone raddeana, underscoring how strongly the modern literature focuses on saponin chemistry and antitumor potential (PMID 29976404).
- A 2020 cell-based study reported anti-breast-cancer activity alongside toxicity observations for total secondary saponins from Anemone raddeana rhizome, reinforcing both pharmacologic interest and the need for caution (PMID 32446927).
PubMed References
- Review of Anemone raddeana Rhizome and its pharmacological effects. (2018)
- Quantitative and qualitative analyses of cytotoxic triterpenoids in the rhizomes of Anemone raddeana using HPLC and HPLC-ESI-Q/TOF-MS. (2018)
- Anti-breast cancer and toxicity studies of total secondary saponin from Anemone raddeana Rhizome on MCF-7 cells via ROS generation and PI3K/AKT/mTOR inactivation. (2020)
Safety & Interactions
Contraindications
- Pregnancy
- Yin-deficient heat patterns
- Weak constitution with poor tolerance for hot toxic herbs
Cautions
- Zhu Jie Xiang Fu is traditionally classed as toxic and should not be treated as a casual daily anti-inflammatory or antitumor supplement.
- Modern cytotoxic and saponin-rich literature may explain pharmacologic activity, but it also strengthens the case for supervision rather than self-treatment.
Conditions
- Rheumatism Traditional ★★★☆☆ JSON
- Joint Pain Traditional ★★★☆☆ JSON
- Abscess Traditional ★★☆☆☆ JSON
- Traumatic Injury Traditional ★★☆☆☆ JSON
Frequently Asked Questions
What is Rhizome of Radde Anemone used for?
Rhizome of Radde Anemone is traditionally used to Dispels wind-damp and relieves stubborn joint pain ... Zhu Jie Xiang Fu is used for cold-damp obstruction, aching limbs, and painful joints with a resistant quality., Reduces swelling and relieves fixed obstructive pain ... traditional use includes painful swellings, neuralgia-type discomfort, and hard obstructive soreness., Resolves toxic swellings in the broader Anemone raddeana tradition ... older use extends to boils, carbuncles, and inflamed lesions where a hot toxic rhizome was chosen.. Research has investigated its effects on: A 2018 review summarized the chemistry and pharmacological effects of Anemone raddeana rhizome and confirmed its longstanding use for neuralgia and rheumatism (PMID 28986812).; A 2018 analytical study profiled cytotoxic triterpenoids in the rhizomes of Anemone raddeana, underscoring how strongly the modern literature focuses on saponin chemistry and antitumor potential (PMID 29976404)..
What are other names for Rhizome of Radde Anemone?
Rhizome of Radde Anemone is also known as Zhu Jie Xiang Fu, Anemone raddeana Rhizome, Trade Anemone Rhizome. In TCM: Rhizoma Anemones Raddeanae.
Is Rhizome of Radde Anemone safe during pregnancy?
Rhizome of Radde Anemone is not recommended during pregnancy.
What are the contraindications for Rhizome of Radde Anemone?
Rhizome of Radde Anemone should not be used in: Pregnancy; Yin-deficient heat patterns; Weak constitution with poor tolerance for hot toxic herbs. Consult a qualified practitioner before use.