Prepared Earthworm

Chinese
制地龙
Pinyin
Zhi Di Long
Latin
Pheretima Praeparata
Scientific specimen plate of Prepared Earthworm, Pheretima, showing processed earthworm sections and diagnostic preparation details.
Botanical plate by Kodi .

Known in TCM as Zhi Di Long (制地龙), this salty, cold herb enters the Bladder, Liver, Lung, and Spleen. Traditionally, it clears heat and extinguishes internal wind ... Zhi Di Long is used for spasms, convulsions, heat-driven agitation, and channel obstruction when internal wind is stirred by replete heat, most often applied for stroke, wheezing, and joint pain. Modern research has identified Lumbrokinase among its active constituents.

Also Known As

Pheretima Processed Di Long

Latin: Pheretima Praeparata | Pinyin: Zhi Di Long | Chinese: 制地龙

TCM Properties

Taste
salty
Temperature
cold
Channels
Bladder, Liver, Lung, Spleen

Traditional Use

Primary Actions

  • Clears heat and extinguishes internal wind ... Zhi Di Long is used for spasms, convulsions, heat-driven agitation, and channel obstruction when internal wind is stirred by replete heat.
  • Unblocks channels and collaterals ... it remains a classic animal medicine for hemiplegia, numbness, painful obstruction, facial paralysis, and post-stroke patterns in which movement is blocked.
  • Clears Lung heat and calms wheezing ... traditional use extends to asthma, difficult breathing, and stubborn wheeze when heat and obstruction bind the Lung.
  • Promotes urination and reduces swelling ... it can be added when edema or difficult urination accompanies heat and obstruction.

Secondary Actions

  • Compared with crude earthworm material, the prepared form is better understood as cleaned, dried, and further processed for more practical medicinal handling rather than as a different therapeutic species.
  • Modern lumbrokinase products are not interchangeable with traditional Zhi Di Long, even though both derive interest from fibrinolytic earthworm chemistry.

Classic Formulas

  • Bu Yang Huan Wu Tang (补阳还五汤) ... classic post-stroke formula in which Di Long helps reopen the channels and collaterals.
  • Di Long with Gou Teng, Jiang Can, and Quan Xie ... internal-wind strategy for spasms, tremors, and convulsions.
  • Di Long with Ma Huang and Xing Ren ... traditional wheezing combination for Lung heat with difficult breathing.

Classical References

  • Traditional herbology preserves Di Long's reputation for treating heat, spasms, and channel obstruction and links its drilling, penetrating animal nature to its collateral-opening action.
  • Preparation is mainly about making the animal material cleaner, drier, and easier to use internally rather than redefining the core medicinal category.
  • PREPARATION NOTE: Zhi Di Long is the processed medicinal form of Pheretima and should not be confused with live or food-grade earthworm material.

Modern Research

Active Compounds

  • Lumbrokinase and related fibrinolytic enzymes ... the best-known earthworm protein fractions associated with antithrombotic research
  • Other fibrinolytic proteins and proteases ... additional earthworm enzymes studied for clot-dissolving activity
  • Nucleosides such as hypoxanthine and inosine ... useful markers in earthworm quality-control work
  • Peptides and amino-acid-rich protein fractions ... broader bioactive materials investigated in anti-inflammatory and antifibrotic models

Studied Effects

  • Oral Pheretima aspergillum improved neurologic recovery in a rat middle-cerebral-artery occlusion model, supporting ongoing interest in stroke and collateral-opening applications (PMID 24082328).
  • Chinese medicine Di-Long from Pheretima vulgaris showed anti-rheumatoid-arthritis effects in preclinical work through NF-kB and Th1-Th2 related pathways, aligning with painful-obstruction use (PMID 35033948).
  • A 2024 meta-analysis concluded that lumbrokinase may have adjunctive potential in acute ischemic stroke, although product standardization and trial quality remain important limitations (PMID 40933244).
  • Heavy-metal and quality-control concerns remain relevant for market Pheretima products, reinforcing the need for authenticated and properly prepared sourcing (PMID 35069214).

PubMed References

Safety & Interactions

Contraindications

  • Cold deficiency patterns without heat, wind, or obstruction
  • Known allergy to animal-derived medicines
  • Active bleeding disorders without close supervision

Cautions

  • Di Long extracts and lumbrokinase-type products may affect coagulation and should be treated more cautiously than the herb's traditional reputation alone might suggest.
  • Commercial Pheretima products can face quality and contamination issues, including documented heavy-metal concerns in some market samples.
  • Prepared earthworm is a potent animal medicine, not a casual supplement or self-care food item.

Drug Interactions

  • Anticoagulants or antiplatelet drugs ... theoretical additive bleeding risk
  • Fibrinolytic or thrombolytic medications ... theoretical additive clot-dissolving effect

Conditions

Frequently Asked Questions

What is Prepared Earthworm used for?

Prepared Earthworm is traditionally used to Clears heat and extinguishes internal wind ... Zhi Di Long is used for spasms, convulsions, heat-driven agitation, and channel obstruction when internal wind is stirred by replete heat., Unblocks channels and collaterals ... it remains a classic animal medicine for hemiplegia, numbness, painful obstruction, facial paralysis, and post-stroke patterns in which movement is blocked., Clears Lung heat and calms wheezing ... traditional use extends to asthma, difficult breathing, and stubborn wheeze when heat and obstruction bind the Lung., Promotes urination and reduces swelling ... it can be added when edema or difficult urination accompanies heat and obstruction.. Research has investigated its effects on: Oral Pheretima aspergillum improved neurologic recovery in a rat middle-cerebral-artery occlusion model, supporting ongoing interest in stroke and collateral-opening applications (PMID 24082328).; Chinese medicine Di-Long from Pheretima vulgaris showed anti-rheumatoid-arthritis effects in preclinical work through NF-kB and Th1-Th2 related pathways, aligning with painful-obstruction use (PMID 35033948)..

What are other names for Prepared Earthworm?

Prepared Earthworm is also known as Pheretima, Processed Di Long. In TCM: 制地龙 (Zhi Di Long); Pheretima Praeparata.

Is Prepared Earthworm safe during pregnancy?

The safety of Prepared Earthworm during pregnancy has not been established. Consult a qualified healthcare provider before use.

What are the contraindications for Prepared Earthworm?

Prepared Earthworm should not be used in: Cold deficiency patterns without heat, wind, or obstruction; Known allergy to animal-derived medicines; Active bleeding disorders without close supervision. Consult a qualified practitioner before use.

Does Prepared Earthworm interact with any medications?

Prepared Earthworm may interact with: Anticoagulants or antiplatelet drugs ... theoretical additive bleeding risk; Fibrinolytic or thrombolytic medications ... theoretical additive clot-dissolving effect. Always inform your healthcare provider of any herbal supplements you are taking.