Black Pepper Fruit … Safety & Interactions

Hu Jiao · Fructus Piperis

Contraindications

  • Stomach heat, reflux with burning, or Yin-deficiency heat

Cautions

  • High-dose pepper extracts or piperine supplements are not equivalent to ordinary culinary use.
  • Concentrated piperine may alter drug absorption or metabolism and can irritate the stomach.
  • Avoid overstating modern research, which remains mostly preclinical or adjunctive.

Drug Interactions

Drug Class / Substrate Mechanism Severity Source
High-dose pepper or piperine preparations may alter the absorption or metabolism of co-administered drugs.

This information is for educational purposes only and does not constitute medical advice. Always consult a qualified healthcare provider before using herbal medicines, especially if you take prescription medications.