Seville Orange Fruit … Safety & Interactions
Zhi Qiao · Fructus Aurantii
Use with caution. Practitioner review recommended before use.
Contraindications
- Pregnancy without qualified supervision
- Marked qi deficiency or prolapse patterns without clear stagnation or distention
Cautions
- Weight-loss or sports-performance bitter-orange extracts are not equivalent to traditional Zhi Qiao decoction material and may deliver much higher p-synephrine exposure.
- Patients with hypertension, palpitations, or stimulant sensitivity should treat concentrated bitter-orange products cautiously, especially when caffeine is also present.
- Because bitter orange contains furanocoumarins and alkaloids relevant to drug metabolism and cardiovascular tone, medication review is important before supplement use.
Drug Interactions
| Drug Class / Substrate | Mechanism | Severity | Source |
|---|---|---|---|
| CYP3A4 substrate drugs - bitter orange contains furanocoumarins that may alter drug metabolism and raise serum levels of susceptible medicines | |||
| Stimulants or caffeine-containing products - combined use may increase cardiovascular stimulation, blood pressure, or palpitations | |||
This information is for educational purposes only and does not constitute medical advice. Always consult a qualified healthcare provider before using herbal medicines, especially if you take prescription medications.