Contraindicated / High risk. Use only under practitioner supervision.
TCM Properties
- Taste
- sweet, bitter, astringent
- Temperature
- warm
- Channels
- Kidney, Spleen, Lung
Traditional Use
Primary Actions
- Warms Kidney yang and restores lower-burner fire - Po Gu Zhi is an older-name record for the same classic herb used in cold weakness, impotence, infertility, and sore low back.
- Secures essence and shrinks urination - it is widely used for spermatorrhea, enuresis, urinary frequency, and other leakage patterns from deficient Kidneys.
- Warms the Spleen and checks chronic dawn diarrhea - it is especially useful when cold deficiency drives early-morning stool with abdominal chill and fatigue.
- Assists the Kidney in grasping qi - traditional combinations use it for chronic wheezing or dyspnea when deficiency prevents the lower burner from receiving breath.
Secondary Actions
- Po Gu Zhi is the older or alternate name commonly written with the character 破, while Bu Gu Zhi is the dominant modern naming form for the same medicinal fruit.
- Like the main Bu Gu Zhi record, this herb also appears in topical vitiligo practice because the source plant contains photosensitizing furocoumarins.
Classic Formulas
- Si Shen Wan - classic dawn-diarrhea formula using Po Gu Zhi or Bu Gu Zhi naming interchangeably in many lineages.
- Qing E Wan and related lumbar-tonic formulas rely on Po Gu Zhi for warming the Kidneys and strengthening the low back.
- Chronic wheezing formulas combine it with Ren Shen, Hu Tao Rou, or Chen Xiang when the Kidney cannot grasp qi.
Classical References
- TCMWiki lists Po Gu Zhi as an accepted naming form and records its warm, sweet-bitter-astringent action on the Kidney, Spleen, and Lung.
- Traditional herbology treats Po Gu Zhi and Bu Gu Zhi as the same classic psoralea fruit rather than as separate medicinals.
Modern Research
Active Compounds
- Psoralen and isopsoralen - hallmark furocoumarins that drive both therapeutic interest and safety concerns
- Bakuchiol - prominent meroterpene frequently discussed in Psoralea studies
- Bavachin and bavachalcone - bioactive flavonoid-type constituents
- Seed polysaccharides - modern fractions investigated for bone and immune effects
Studied Effects
- A 2018 review covered the ethnobotanical, biological, and chemical aspects of Psoralea corylifolia, giving a broad overview relevant to both Bu Gu Zhi and Po Gu Zhi naming traditions (PMID 29243333).
- A 2025 study reported anti-osteoclast and anti-osteoporosis effects of polysaccharides from Psoralea corylifolia seeds in preclinical work (PMID 40403806).
- A 2019 rat study highlighted hepatotoxicity after long-term exposure to psoralen and isopsoralen, reinforcing the main safety concern for concentrated Psoralea use (PMID 31684074).
PubMed References
Safety & Interactions
Contraindications
- Yin deficiency with heat or deficiency fire
- Constipation from dryness or internal heat
- Active liver disease without qualified supervision
Cautions
- Psoralea fruit carries hepatotoxic risk, especially in concentrated extracts, prolonged courses, or unsupervised high dosing.
- Its psoralen compounds can increase photosensitivity, particularly in topical or strongly extracted preparations.
- MSK page not found - drug interaction data not available from Memorial Sloan Kettering integrative medicine database