Psoralea Fruit

Chinese
破故纸
Pinyin
Po Gu Zhi
Latin
Fructus Psoraleae Corylifoliae

TCM Properties

Taste
sweet, bitter, astringent
Temperature
warm
Channels
Kidney, Spleen, Lung

Traditional Use

Primary Actions

  • Warms Kidney yang and restores lower-burner fire - Po Gu Zhi is an older-name record for the same classic herb used in cold weakness, impotence, infertility, and sore low back.
  • Secures essence and shrinks urination - it is widely used for spermatorrhea, enuresis, urinary frequency, and other leakage patterns from deficient Kidneys.
  • Warms the Spleen and checks chronic dawn diarrhea - it is especially useful when cold deficiency drives early-morning stool with abdominal chill and fatigue.
  • Assists the Kidney in grasping qi - traditional combinations use it for chronic wheezing or dyspnea when deficiency prevents the lower burner from receiving breath.

Secondary Actions

  • Po Gu Zhi is the older or alternate name commonly written with the character 破, while Bu Gu Zhi is the dominant modern naming form for the same medicinal fruit.
  • Like the main Bu Gu Zhi record, this herb also appears in topical vitiligo practice because the source plant contains photosensitizing furocoumarins.

Classic Formulas

  • Si Shen Wan - classic dawn-diarrhea formula using Po Gu Zhi or Bu Gu Zhi naming interchangeably in many lineages.
  • Qing E Wan and related lumbar-tonic formulas rely on Po Gu Zhi for warming the Kidneys and strengthening the low back.
  • Chronic wheezing formulas combine it with Ren Shen, Hu Tao Rou, or Chen Xiang when the Kidney cannot grasp qi.

Classical References

  • TCMWiki lists Po Gu Zhi as an accepted naming form and records its warm, sweet-bitter-astringent action on the Kidney, Spleen, and Lung.
  • Traditional herbology treats Po Gu Zhi and Bu Gu Zhi as the same classic psoralea fruit rather than as separate medicinals.

Modern Research

Active Compounds

  • Psoralen and isopsoralen - hallmark furocoumarins that drive both therapeutic interest and safety concerns
  • Bakuchiol - prominent meroterpene frequently discussed in Psoralea studies
  • Bavachin and bavachalcone - bioactive flavonoid-type constituents
  • Seed polysaccharides - modern fractions investigated for bone and immune effects

Studied Effects

  • A 2018 review covered the ethnobotanical, biological, and chemical aspects of Psoralea corylifolia, giving a broad overview relevant to both Bu Gu Zhi and Po Gu Zhi naming traditions (PMID 29243333).
  • A 2025 study reported anti-osteoclast and anti-osteoporosis effects of polysaccharides from Psoralea corylifolia seeds in preclinical work (PMID 40403806).
  • A 2019 rat study highlighted hepatotoxicity after long-term exposure to psoralen and isopsoralen, reinforcing the main safety concern for concentrated Psoralea use (PMID 31684074).

PubMed References

Safety & Interactions

Contraindications

  • Yin deficiency with heat or deficiency fire
  • Constipation from dryness or internal heat
  • Active liver disease without qualified supervision

Cautions

  • Psoralea fruit carries hepatotoxic risk, especially in concentrated extracts, prolonged courses, or unsupervised high dosing.
  • Its psoralen compounds can increase photosensitivity, particularly in topical or strongly extracted preparations.
  • MSK page not found - drug interaction data not available from Memorial Sloan Kettering integrative medicine database

Conditions