Contraindicated / High risk. Use only under practitioner supervision.
TCM Properties
- Taste
- sweet, bitter, astringent
- Temperature
- warm
- Channels
- Kidney, Spleen, Lung
Traditional Use
Primary Actions
- Warms the Kidney and tonifies yang - Bu Gu Zhi is used for cold low back, weak knees, impotence, infertility, and depleted Kidney fire.
- Secures essence and reduces urination - it is a standard herb for frequent urination, enuresis, spermatorrhea, and lower-burner leakage rooted in Kidney deficiency.
- Warms the Spleen and stops dawn diarrhea - it is especially valued when early-morning loose stool reflects chronic Spleen-Kidney yang deficiency.
- Helps the Kidney grasp qi - it is added to formulas for chronic wheezing or dyspnea when lower-source weakness prevents proper grasp of breath.
Secondary Actions
- Traditional and modern practice also uses Bu Gu Zhi externally, especially in vitiligo-focused preparations because of its photosensitizing psoralen compounds.
- It is a strong warm-astringent herb rather than a gentle tonic, so it works best when cold, leakage, and lower-burner weakness are all clearly present.
Classic Formulas
- Si Shen Wan - classic dawn-diarrhea formula using Bu Gu Zhi to warm the Spleen and Kidney and secure chronic early-morning stool.
- Qing E Wan - lower-back and Kidney-yang formula pairing Bu Gu Zhi with Du Zhong and other supportive ingredients for lumbar weakness.
- Kidney grasping-qi lineages pair Bu Gu Zhi with Ren Shen, Hu Tao Rou, or Chen Xiang for chronic wheezing from lower-source deficiency.
Classical References
- TCMWiki records Bu Gu Zhi as sweet, bitter, astringent, and warm, entering the Kidney, Spleen, and Lung to warm yang, secure leakage, stop diarrhea, and relieve dyspnea.
- Traditional materia medica repeatedly distinguishes its hot, drying, astringing nature from the gentler balanced Kidney tonics such as Tu Si Zi.
Modern Research
Active Compounds
- Psoralen and isopsoralen - hallmark furocoumarins responsible for much of the herb's research and safety profile
- Bakuchiol - a notable meroterpene frequently discussed in Psoralea pharmacology
- Bavachin and bavachalcone - flavonoid-type constituents studied in bone and inflammatory models
- Seed polysaccharides - emerging fractions in modern osteoporosis and immune research
Studied Effects
- A 2018 review summarized the ethnobotanical, biological, and chemical aspects of Psoralea corylifolia, providing the main broad overview of Bu Gu Zhi research (PMID 29243333).
- A 2025 study reported that polysaccharides from Psoralea corylifolia seeds suppressed osteoclastogenesis and alleviated osteoporosis in preclinical work, reinforcing continued bone-health interest (PMID 40403806).
- A 2019 rat study found that long-term exposure to psoralen and isopsoralen induced hepatotoxicity and altered serum metabolites, underscoring one of the herb's key safety concerns (PMID 31684074).
PubMed References
Safety & Interactions
Contraindications
- Yin deficiency with heat or deficiency fire
- Constipation from fluid depletion or excessive internal heat
- Active liver disease without qualified supervision
Cautions
- Psoralen-rich Bu Gu Zhi can be hepatotoxic, especially in concentrated products, prolonged use, or poorly supervised dosing.
- The herb is photosensitizing and may increase skin sensitivity to ultraviolet exposure, particularly in topical or extract form.
- MSK page not found - drug interaction data not available from Memorial Sloan Kettering integrative medicine database