Use with caution. Review interactions and contraindications below.
TCM Properties
- Taste
- sour, sweet, bitter, pungent, salty
- Temperature
- warm
- Channels
- Lung, Heart, Kidney
Traditional Use
Primary Actions
- Restrains the Lung and stops chronic cough or wheezing - Bei Wu Wei Zi is used when leakage of Lung qi causes prolonged cough, wheezing, or weak grasp of breath.
- Generates fluids and checks leakage - it is used for spontaneous sweating, night sweats, thirst, dry mouth, and fluid loss after chronic illness or summer-heat damage.
- Binds the intestines and secures essence - chronic diarrhea and essence leakage patterns are classic indications when deficiency underlies leakage.
- Calms the Heart and tonifies the Kidney - it also appears in formulas for palpitations, insomnia, and Heart-Kidney disharmony.
Secondary Actions
- This record specifically refers to the northern species Schisandra chinensis, the preferred tonic-standard medicinal berry in the pharmacopoeial distinction between northern and southern Wu Wei Zi.
- Northern and southern Schisandra are related but not chemically identical, and the northern species is typically favored for richer lignan content and tonic use.
Classic Formulas
- Sheng Mai San - classic three-herb formula using Bei Wu Wei Zi to restrain leakage of qi and fluids while supporting the Heart and Lung.
- Xiao Qing Long Tang - uses Wu Wei Zi to prevent over-dispersion while cough, wheezing, and cold-phlegm are treated.
- Si Shen Wan and similar deficiency-leakage lineages use Wu Wei Zi to bind the intestines and secure chronic diarrhea.
Classical References
- Traditional Fructus Schisandrae materia medica notes that Schisandra chinensis is the northern source, Bei Wu Wei Zi, and is preferred over the southern species for standard medicinal use.
- Classical descriptions emphasize the five flavors, warm nature, and entry into the Lung, Heart, and Kidney to astringe, generate fluids, calm the spirit, and secure essence.
Modern Research
Active Compounds
- Schisandrin - one of the hallmark lignans of Schisandra chinensis
- Schisandrol A - major lignan associated with neuroprotective and hepatoprotective research
- Gomisin C and gomisin G - interaction-relevant lignans with CYP and transporter significance
- Schisantherin A - anti-inflammatory lignan frequently discussed in Schisandra pharmacology
Studied Effects
- A 2019 review summarized the health and nutrition potential of Schisandra chinensis, including antioxidant, hepatoprotective, and adaptogenic research directions (PMID 30720717).
- A 2024 review focused on schisandrin and described sedative, antioxidant, immunomodulatory, and liver-related pharmacologic features while noting bioavailability limitations (PMID 37658213).
- A review of Schisandra fructus and its active ingredients highlighted promising neurological-disease applications in preclinical research (PMID 29986408).
PubMed References
Safety & Interactions
Contraindications
- Active exterior pathogen when venting is still required
- Acute excess Lung heat or acute damp-heat diarrhea
- Marked phlegm-fluid retention that should be dispersed rather than constrained
Cautions
- MSK notes that Schisandra may alter metabolism or transport of some drugs through CYP1A2, CYP3A4, CYP3A5, and P-glycoprotein effects.
- Northern and southern Schisandra are not fully interchangeable because their lignan profiles differ.
- Schisandra can reduce certain liver-enzyme lab values, which matters when interpreting follow-up testing.
Drug Interactions
- CYP1A2, CYP3A4, and CYP3A5 substrates - lignans may inhibit or otherwise alter metabolism of susceptible drugs
- P-glycoprotein substrates - Schisandra may affect transport and increase side-effect risk
- Tacrolimus - coadministration can raise tacrolimus exposure