Northern Schisandra Fruit

Chinese
北五味子
Pinyin
Bei Wu Wei
Latin
Fructus Schisandrae

TCM Properties

Taste
sour, sweet, bitter, pungent, salty
Temperature
warm
Channels
Lung, Heart, Kidney

Traditional Use

Primary Actions

  • Restrains the Lung and stops chronic cough or wheezing - Bei Wu Wei Zi is used when leakage of Lung qi causes prolonged cough, wheezing, or weak grasp of breath.
  • Generates fluids and checks leakage - it is used for spontaneous sweating, night sweats, thirst, dry mouth, and fluid loss after chronic illness or summer-heat damage.
  • Binds the intestines and secures essence - chronic diarrhea and essence leakage patterns are classic indications when deficiency underlies leakage.
  • Calms the Heart and tonifies the Kidney - it also appears in formulas for palpitations, insomnia, and Heart-Kidney disharmony.

Secondary Actions

  • This record specifically refers to the northern species Schisandra chinensis, the preferred tonic-standard medicinal berry in the pharmacopoeial distinction between northern and southern Wu Wei Zi.
  • Northern and southern Schisandra are related but not chemically identical, and the northern species is typically favored for richer lignan content and tonic use.

Classic Formulas

  • Sheng Mai San - classic three-herb formula using Bei Wu Wei Zi to restrain leakage of qi and fluids while supporting the Heart and Lung.
  • Xiao Qing Long Tang - uses Wu Wei Zi to prevent over-dispersion while cough, wheezing, and cold-phlegm are treated.
  • Si Shen Wan and similar deficiency-leakage lineages use Wu Wei Zi to bind the intestines and secure chronic diarrhea.

Classical References

  • Traditional Fructus Schisandrae materia medica notes that Schisandra chinensis is the northern source, Bei Wu Wei Zi, and is preferred over the southern species for standard medicinal use.
  • Classical descriptions emphasize the five flavors, warm nature, and entry into the Lung, Heart, and Kidney to astringe, generate fluids, calm the spirit, and secure essence.

Modern Research

Active Compounds

  • Schisandrin - one of the hallmark lignans of Schisandra chinensis
  • Schisandrol A - major lignan associated with neuroprotective and hepatoprotective research
  • Gomisin C and gomisin G - interaction-relevant lignans with CYP and transporter significance
  • Schisantherin A - anti-inflammatory lignan frequently discussed in Schisandra pharmacology

Studied Effects

  • A 2019 review summarized the health and nutrition potential of Schisandra chinensis, including antioxidant, hepatoprotective, and adaptogenic research directions (PMID 30720717).
  • A 2024 review focused on schisandrin and described sedative, antioxidant, immunomodulatory, and liver-related pharmacologic features while noting bioavailability limitations (PMID 37658213).
  • A review of Schisandra fructus and its active ingredients highlighted promising neurological-disease applications in preclinical research (PMID 29986408).

PubMed References

Safety & Interactions

Contraindications

  • Active exterior pathogen when venting is still required
  • Acute excess Lung heat or acute damp-heat diarrhea
  • Marked phlegm-fluid retention that should be dispersed rather than constrained

Cautions

  • MSK notes that Schisandra may alter metabolism or transport of some drugs through CYP1A2, CYP3A4, CYP3A5, and P-glycoprotein effects.
  • Northern and southern Schisandra are not fully interchangeable because their lignan profiles differ.
  • Schisandra can reduce certain liver-enzyme lab values, which matters when interpreting follow-up testing.

Drug Interactions

  • CYP1A2, CYP3A4, and CYP3A5 substrates - lignans may inhibit or otherwise alter metabolism of susceptible drugs
  • P-glycoprotein substrates - Schisandra may affect transport and increase side-effect risk
  • Tacrolimus - coadministration can raise tacrolimus exposure

Conditions