Feverfew may add to the effects of anticoagulant or antiplatelet medicines. Laboratory research also suggests inhibition of several CYP enzymes, but the clinical importance of those metabolism findings is not known.

Use with caution. Healthcare professional review recommended before use.

Contraindications

Pregnancy
Known allergy to ragweed, chrysanthemums, marigolds, daisies, or related plants
Use before scheduled surgery

Cautions

Feverfew may slow blood clotting and should be stopped before surgery.
Chewing fresh leaves can cause mouth sores and irritation.
Abrupt discontinuation after long-term use has been associated with stiffness, anxiety, and pain.

Drug Interactions

Drug Class / Substrate	Mechanism	Severity	Source
Anticoagulants and antiplatelet medicines	Parthenolide can inhibit platelet activity and may increase bleeding risk.	Major	Memorial Sloan Kettering About Herbs
CYP1A2, CYP2C8, CYP2C9, CYP2C19, CYP2D6, and CYP3A4 substrate medicines	Laboratory inhibition may alter drug concentrations, but clinical relevance is not known.	Uncertain	Memorial Sloan Kettering About Herbs

Pregnancy

Not recommended during pregnancy. Consult a qualified healthcare provider before any use.

This information is for educational purposes only and does not constitute medical advice. Always consult a qualified healthcare provider before using herbal medicines, especially if you take prescription medications.