Earthworm

Chinese
地龙
Pinyin
Di Long
Latin
Pheretima

TCM Properties

Taste
salty
Temperature
cold
Channels
Bladder, Liver, Lung, Spleen

Traditional Use

Primary Actions

  • Clears heat and extinguishes internal wind - Di Long is classically used for high fever, spasms, convulsions, and heat-driven agitation in which internal wind has been stirred by replete heat.
  • Unblocks channels and collaterals - it is a core animal medicine for hemiplegia, numbness, facial paralysis, red swollen painful obstruction, and post-stroke patterns where movement has been blocked by stasis and heat.
  • Clears Lung heat and calms wheezing - traditional use extends to asthma, labored breathing, and stubborn wheeze when heat and obstruction bind the Lung.
  • Promotes urination and reduces swelling - it can be added when bladder heat, edema, or difficult urination are part of the pattern.

Secondary Actions

  • Di Long is prized for strong channel-opening action and is usually chosen when a formula needs something more penetrating than ordinary plant herbs.
  • Modern extract products such as lumbrokinase are not interchangeable with crude TCM earthworm and should not be treated as simple equivalents.

Classic Formulas

  • Bu Yang Huan Wu Tang - classic post-stroke formula in which Di Long helps reopen the channels and collaterals.
  • Di Long with Gou Teng, Jiang Can, and Quan Xie - a traditional internal-wind combination for spasms, tremors, and convulsions.
  • Di Long with Ma Huang and Xing Ren - a classic wheezing strategy for Lung heat with difficult breathing.

Classical References

  • Shen Nong Ben Cao Jing and later materia medica preserve Di Long's reputation for treating heat, spasms, and channel obstruction.
  • Traditional herbology links its animal, drilling, penetrating character to its ability to reach the collaterals and unblock what is stuck.
  • Modern pharmacopoeias distinguish several official source species but preserve the same broad functional profile of clearing heat, stopping spasms, and opening the channels.

Modern Research

Active Compounds

  • Lumbrokinase and related fibrinolytic enzymes - the best-known protein fraction associated with antithrombotic research
  • Other fibrinolytic proteins and proteases - additional earthworm enzymes studied for clot-dissolving activity
  • Nucleosides such as hypoxanthine, inosine, and related small molecules - important markers in earthworm quality-control work
  • Peptides and amino acid-rich protein fractions - broader bioactive material investigated in anti-inflammatory and antifibrotic models

Studied Effects

  • Oral Pheretima aspergillum improved neurologic recovery in a rat middle-cerebral-artery occlusion model, supporting ongoing interest in stroke and collateral-opening applications (PMID 24082328).
  • Chinese medicine Di-Long from Pheretima vulgaris showed anti-rheumatoid-arthritis effects in preclinical work through NF-kB and chemotaxis-related pathways, aligning with traditional painful-obstruction use (PMID 35033948).
  • A 2024 meta-analysis concluded that lumbrokinase may have adjunctive potential in acute ischemic stroke, but product standardization and trial quality remain important limitations (PMID 40933244).

PubMed References

Safety & Interactions

Contraindications

  • Cold deficiency patterns without heat, wind, or obstruction
  • Known allergy to animal-derived medicines
  • Active bleeding disorders without close supervision

Cautions

  • Di Long extracts and lumbrokinase-type products may affect coagulation and should be treated more cautiously than the herb's traditional reputation alone might suggest.
  • Commercial Pheretima products can face quality and contamination issues, including documented heavy-metal concerns in some market samples.
  • MSK page not found - drug interaction data not available from Memorial Sloan Kettering integrative medicine database

Drug Interactions

  • Anticoagulants or antiplatelet drugs - theoretical additive bleeding risk
  • Fibrinolytic or thrombolytic medications - theoretical additive clot-dissolving effect

Conditions

  • Stroke Research ★★★☆☆
  • Asthma Traditional ★★★☆☆
  • Joint Pain Traditional ★★★☆☆
  • Edema Traditional ★★☆☆☆