Corydalis Tuber

Chinese
延胡索
Pinyin
Yan Hu Suo
Latin
Rhizoma Corydalis

TCM Properties

Taste
acrid, bitter
Temperature
warm
Channels
Heart, Liver, Spleen

Traditional Use

Primary Actions

  • Invigorates Blood, moves Qi, and relieves pain - Yan Hu Suo is one of the signature pain herbs of Chinese medicine because it treats both Qi stagnation and Blood stasis, especially when fixed pain and distension coexist.
  • Relieves chest, flank, epigastric, and abdominal pain - it is widely used for digestive, menstrual, and constrained Liver-type pain patterns rather than for simple deficiency aches.
  • Addresses traumatic and gynecologic pain - classical use extends to dysmenorrhea, postpartum abdominal pain, traumatic injury, and painful obstruction when movement of stagnation is required.

Secondary Actions

  • Vinegar-processing is a major traditional refinement for Yan Hu Suo because it is thought to direct the herb more strongly toward the Blood level and pain-relieving function.
  • The herb is not merely warming; its importance lies in the unusual combination of moving both Qi and Blood in one medicine.

Classic Formulas

  • Jin Ling Zi San - classic pairing with Chuan Lian Zi for hypochondriac, epigastric, and lower-abdominal pain from constrained Liver Qi with heat or stasis.
  • Yan Hu Suo Zhi Tong Wan - patent-style pain formula built around corydalis for generalized stagnation pain patterns.
  • Shao Fu Zhu Yu Tang - gynecologic stasis formula where Yan Hu Suo assists movement and pain relief in the lower abdomen.
  • Shi Xiao San modifications - used in menstrual and traumatic pain presentations where Blood stasis is acute and painful.

Classical References

  • Materia medica tradition consistently treats Yan Hu Suo as a premier analgesic herb that moves both Qi and Blood, making it unusually versatile across chest, abdominal, and gynecologic pain.
  • Older clinicians often emphasized vinegar-processed Yan Hu Suo for stronger pain relief, a pattern that modern processing research still examines today.
  • Its warm, acrid, bitter profile explains why it is directed at obstructive pain rather than at pain from simple empty deficiency.

Modern Research

Active Compounds

  • Tetrahydropalmatine - the best known alkaloid associated with analgesic and sedative effects
  • Dehydrocorybulbine - a pain-related alkaloid studied in neuropathic and inflammatory models
  • Protopine and related isoquinoline alkaloids - supportive constituents within the broader corydalis alkaloid profile
  • Quaternary and tertiary alkaloid fractions - the main pharmacologically active chemical families in Yan Hu Suo

Studied Effects

  • A 2021 review summarized the analgesic chemistry of Corydalis yanhusuo and highlighted its rich alkaloid profile as the basis for the herb's enduring reputation as a pain medicine (PMID 34946576).
  • Experimental work showed that Corydalis yanhusuo extract has significant antinociceptive activity across inflammatory and neuropathic pain models, supporting its broad traditional use for painful stagnation (PMID 27622550).
  • A 2022 review of processing, compatibility, pharmacology, pharmacokinetics, and safety underscored that vinegar-processing changes efficacy and toxicity considerations and remains central to modern understanding of Yan Hu Suo (PMID 35003289).

PubMed References

Safety & Interactions

Contraindications

  • Pregnancy
  • Heavy menstrual bleeding without stasis
  • Severe Qi or Blood deficiency pain without obstruction

Cautions

  • Yan Hu Suo is a moving pain herb and can be too dispersing when there is active bleeding or clear deficiency without stasis.
  • Its alkaloids may cause dizziness, sedation, or gastrointestinal upset in sensitive patients or excessive doses.
  • Recent literature also raises concern about potential idiosyncratic hepatotoxicity, so prolonged unsupervised use is not ideal.
  • MSK page not found - drug interaction data not available from Memorial Sloan Kettering integrative medicine database

Conditions