Chrysanthemum Flower — Safety & Interactions
Ju Hua · Flos Chrysanthemi Morifolii
Use with caution. Practitioner review recommended before use.
Contraindications
- Ragweed or Asteraceae family allergy — cross-reactivity risk
- Patients on immunosuppressive drugs — documented case of toxic drug levels in kidney transplant recipient consuming chrysanthemum tea (MSK)
Cautions
- Use with caution in qi deficiency, chronic diarrhea, or poor appetite — cool nature may aggravate cold patterns
- May cause contact dermatitis or photosensitivity with topical or prolonged exposure
- Large doses may cause dizziness in sensitive individuals
Drug Interactions
| Drug Class / Substrate | Mechanism | Severity | Source |
|---|---|---|---|
| CYP3A4 substrates (immunosuppressants, certain statins, calcium channel blockers) | Chrysanthemum extracts can both induce and inhibit CYP3A4 activity, potentially altering drug blood levels | Moderate | Memorial Sloan Kettering Integrative Medicine — Chrysanthemum |
| P-glycoprotein (P-gp) substrates | Chrysanthemum inhibits P-gp efflux transporter, increasing intracellular concentrations of substrate drugs | Moderate | Memorial Sloan Kettering Integrative Medicine — Chrysanthemum |
This information is for educational purposes only and does not constitute medical advice. Always consult a qualified healthcare provider before using herbal medicines, especially if you take prescription medications.