Blackberrylily Rhizome

Chinese
射干
Pinyin
She Gan
Latin
Belamcandae Rhizoma

TCM Properties

Taste
bitter
Temperature
cold
Channels
Lung

Traditional Use

Primary Actions

  • Clears heat toxin and benefits the throat - one of the classic herbs for swollen painful throat, hoarseness, and pharyngeal obstruction from toxic heat or phlegm-heat lodged in the throat.
  • Clears Lung heat, transforms phlegm, and directs Lung Qi downward - used for cough, wheezing, noisy breathing, and thick sputum when phlegm-heat obstructs the Lung and throat.
  • Disperses nodules and toxic swellings - extended to scrofula, abscesses, and hot swollen lesions when toxin, phlegm, and local stagnation combine.
  • Can treat both hot and cold-phlegm wheezing when paired appropriately - although naturally cold, classical formulas also use it with warming herbs to open phlegm obstruction in cold-type asthma.

Secondary Actions

  • She Gan remains the classical pharmacognostic name even though the source plant is often treated botanically as Iris domestica rather than Belamcanda chinensis in newer taxonomic systems.
  • Its strongest traditional reputation is throat-focused, making it a go-to medicinal for acute toxic heat in the pharynx rather than a broad general tonic.

Classic Formulas

  • She Gan Ma Huang Tang (射干麻黄汤) - from Jin Gui Yao Lue, using She Gan with Ma Huang, Ban Xia, Xi Xin, and Zi Wan for cough and wheezing with phlegm obstructing the throat.
  • She Gan Tang (射干汤) - single-herb and modified throat formulas recorded in later literature for severe swollen painful throat due to heat toxin.
  • She Gan Xiao Du Yin (射干消毒饮) - used for wind-heat or toxic throat swelling with hoarseness, pain, and redness, highlighting She Gan's detoxifying and throat-opening role.

Classical References

  • Shen Nong Ben Cao Jing records She Gan for throat obstruction and painful throat, establishing its long classical identity as a key pharyngeal medicinal.
  • TCM Wiki and Me and Qi both describe She Gan as bitter and cold, entering the Lung channel and classically used to clear toxic heat, dispel phlegm, and relieve sore throat.
  • Traditional cautions consistently note that She Gan is contraindicated in pregnancy and should be used carefully in weak patients with loose stools.

Modern Research

Active Compounds

  • Tectoridin (isoflavone glycoside) - one of the major characteristic constituents used in chemical profiling of She Gan
  • Tectorigenin (isoflavone aglycone) - a signature anti-inflammatory and antitumor research constituent
  • Iridin and irigenin (isoflavone glycoside and aglycone) - important paired constituents repeatedly highlighted in pharmacology studies
  • Irisflorentin (isoflavone) - one of the classical marker compounds of the rhizome
  • Iridal-type triterpenoids (triterpenoids) - newer constituents linked with neutrophil elastase inhibition and anti-inflammatory activity

Studied Effects

  • Comprehensive review literature supports She Gan's long-standing anti-inflammatory, antioxidant, antimicrobial, and antitumor research profile while tying these findings back to the traditional throat and phlegm indications (PMID 41375398; PMID 27032710)
  • Irigenin inhibited nitric oxide and prostaglandin E2 production in activated macrophages, providing a mechanistic correlate for the herb's heat-toxin and sore-throat uses (PMID 16307761)
  • Iridal-type triterpenoids from Belamcanda chinensis showed human neutrophil elastase inhibition and anti-inflammatory activity, supporting modern interest in airway and inflammatory applications (PMID 34771010)
  • Belamcanda chinensis extract inhibited non-small cell lung cancer cell proliferation and induced apoptosis in preclinical work, adding to ongoing oncology-related interest in the rhizome's isoflavones (PMID 39229537)

PubMed References

Safety & Interactions

Contraindications

  • Pregnancy
  • Loose stools or poor appetite due to Spleen deficiency-cold

Cautions

  • Because She Gan is bitter and cold, prolonged use may weaken digestion in already depleted patients
  • It is classically reserved for true toxic-heat, phlegm-heat, or obstructive throat patterns rather than simple deficiency hoarseness
  • MSK page not found - drug interaction data not available from Memorial Sloan Kettering integrative medicine database

Conditions