Tonifies the Liver and Kidney and preserves essence — used for dizziness, tinnitus, sore lower back, weak knees, and chronic Liver-Kidney deficiency patterns
Astringes and secures leakage — stops seminal emission, frequent urination, enuresis, and excessive sweating from deficient Kidney restraint
Rescues collapse by restraining the outward loss of Qi and Yin — classical high-dose use for profuse sweating, faint pulse, and devastated Yang or Yin collapse
Astringes to stop uterine bleeding — used when Chong and Ren instability from Liver-Kidney deficiency causes prolonged or excessive bleeding
Secondary Actions
Supports Xiao Ke / wasting-thirst patterns with excessive urination rooted in Kidney deficiency
Wine-processed form is favored for chronic tonic formulas, while raw form is used when stronger astringent rescue action is desired
Classic Formulas
Liu Wei Di Huang Wan (六味地黄丸) — foundational Kidney Yin formula in which Shan Zhu Yu helps tonify the Liver and Kidney while securing the essence
Zuo Gui Wan (左归丸) — enriches Kidney Yin and essence; Shan Zhu Yu helps prevent leakage while the richer tonics replenish
Lai Fu Tang (来复汤) — rescue formula using high-dose Shan Zhu Yu with Long Gu and Mu Li for collapse with profuse sweating and scattered Qi and Yin
Classical References
Xiao Er Yao Zheng Zhi Jue (Song dynasty) — Liu Wei Di Huang Wan uses Shan Zhu Yu as one of the three tonifying fruits to enrich Kidney Yin while retaining essence.
Jing Yue Quan Shu (Ming dynasty) — Zuo Gui Wan and related Kidney-tonifying formulas use Shan Zhu Yu to nourish the Liver and Kidney while preventing leakage of essence.
Zhang Xichun medical case tradition (late Qing / early Republic) — Lai Fu Tang elevated Shan Zhu Yu as a major rescue herb for collapse with profuse sweating and scattered Qi and Yin.
Antidiabetic and nephroprotective — Cornus officinalis and its iridoids show glucose-lowering, renal-protective, and anti-fibrotic relevance in diabetic nephropathy research (PMID 37475719)
Anti-inflammatory, antioxidant, and neuroprotective — review literature identifies broad multi-system pharmacology consistent with traditional Liver-Kidney tonic use (PMID 33912050)
Anti-hepatic-fibrosis — processed Cornus officinalis enhanced anti-fibrotic effects through the SIRT3-AMPK axis in experimental models (PMID 38646453)