Hepatoprotective — reduces liver enzyme elevation in hepatobiliary disease
Addresses headache associated with Liver-Gallbladder Fire
Classical References
Tibetan Pharmacopoeia chronicles record the genus Chrysosplenium (Tibetan: Yajima) for removing undesired Heat, treating acute icteric hepatitis, and acute liver necrosis — the closest classical tradition for this folk herb
Chrysosplenium sinicum Maxim. (中华金腰 Zhong Hua Jin Yao) is documented in Chinese folk medicine of southwest China as a remedy for cholecystitis and cholelithiasis
Hepatoprotective: Chrysosplenium nudicaule extract reduced serum AST, ALT, ALP, and bilirubin in ANIT-induced intrahepatic cholestasis mice; mechanism involves activating FXR and BSEP/MRP2 transporter genes to reduce bile acid synthesis and enhance biliary excretion (PMID 30989870)
Flavonoid profile characterised in C. alternifolium by HPLC; chrysosplenoside B and D and chrysosplenol B and D identified as quality-control markers with total flavonoid content 2.5–4.3% dry weight (PMID 19615839)
Genomic analysis of C. sinicum confirmed high-level expression of flavonoid biosynthesis genes; chrysosplenol and chrysosplenoside identified as characteristic bioactive components (PMID 39152309)